Is Allulose Safe?
The FDA has not objected to three generally recognized as safe (GRAS) notifications, GRN 400, GRN 498 and GRN 693, for the use of allulose as a sugar substitute in certain conventional foods and beverages. That is the FDA's regulatory position, not a test result of our own.
Allulose, or D-psicose, is a monosaccharide and an epimer of fructose that the FDA says occurs naturally in small amounts in wheat, in fruits such as raisins and dried figs, and in foods such as molasses, maple syrup and brown sugar. The FDA concluded its caloric contribution is very low, no more than 0.4 calories per gram, because most allulose is excreted intact in the urine and it is poorly fermented in the gut.
On labels, the FDA's October 2020 final guidance says it intends to exercise enforcement discretion so manufacturers can leave allulose out of Total Sugars and Added Sugars and use 0.4 calories per gram when calculating Calories, pending a rulemaking. That followed a draft the FDA announced in the Federal Register of April 18, 2019. Allulose must still be declared in the ingredient statement, the FDA notes, so consumers can tell when it is in a food.
Sources checked September 15, 2026. Every point below links the page it came from.
The sources behind this answer
- Regulatory filingThe FDA says it has not objected to three GRAS notifications, GRN 400, GRN 498 and GRN 693, on the use of allulose as a sugar substitute in certain conventional foods and beverages. US FDA ↗
- Government sourceThe FDA describes allulose, or D-psicose, as a monosaccharide that occurs naturally in small amounts in wheat, raisins, dried figs, molasses, maple syrup and brown sugar. US FDA ↗
- Regulatory filingThe FDA intends to exercise enforcement discretion for excluding allulose from Total Sugars and Added Sugars and for using 0.4 calories per gram for allulose on Nutrition and Supplement Facts labels, pending rulemaking. US FDA ↗
- Government sourceThe FDA concluded allulose contributes no more than 0.4 calories per gram because most of it is excreted intact in the urine and it is poorly fermented in the gut. US FDA ↗
- Regulatory filingThe FDA announced a draft version of its allulose labeling guidance in the Federal Register of April 18, 2019. US FDA ↗
- Regulatory filingThe FDA says allulose must be declared in the ingredient statement if it is present in a product, so consumers can determine when it is an ingredient. US FDA ↗
Sources checked September 15, 2026. A brand statement is the company’s own claim, which we report but have not verified. Our grades are model-based estimates, not lab tests.